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Downstream migration is mediated by self-secreted ligands, specifically CCL19 and CCL21, which bind to the chemokine receptor CCR7 [233]

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However, years later in 2016, a pharmacological analysis of this ligand demonstrated interspecies differences between the rodent and human GIP system and also led to the conclusion that the human Pro3(GIP) was a potent partial agonist with the ability to activate the human GIP receptor with a maximal efficiency (E max ) of 90% compared to human GIP (68)